This paper systematically studied the material compatibility, storage stability, and miscibility with diesel fuel of polyoxymethylene dimethyl ethers (PODE _n ) from the point of view of its application performance. The results show that the PODE _n is generally highly compatible with common metal materials, such as copper, brass, steel, cast iron, cast aluminum, and solder. In comparison, blended diesel fuel with PODE _n at a volume fraction of 10% is highly compatible with polyester polyurethane rubber and fluororubber but poorly compatible with nitrile rubber and polyether polyurethane rubber. In the storage stability test conducted at 43 °C for 16 weeks, PODE _n demonstrates satisfactory storage stability. Excellent miscibility stability occurs after the blending of automobile diesel fuel with PODE _n at a volume fraction of 10%. In general, as a component of blended diesel fuel, PODE _n delivers satisfactory application performance.